129 Pervasive immune dysfunction characterizes photoaged skin
نویسندگان
چکیده
Long-term sun exposure markedly accelerates the skin changes of chronological aging, leading to deterioration function and appearance in a process termed Photoaging. The molecular mechanisms underlying photoaging remain incompletely defined, due largely limitations ex vivo studies. To interrogate this phenomenon vivo, we performed single-cell RNA-seq sun-protected sun-exposed from four ∼20-year-old (yo) ∼90yo donors. Clustering annotation resulting cells revealed pervasive immune dysfunction photoaged skin. Relative all other types, (sun-exposed, 90yo) showed decreased resident memory T cells, increased regulatory accumulation IL10+ dendritic which were reported dampen excessive inflammation. Inflammatory responses also perturbed non-immune skin, including keratinocytes. Fibroblasts stromal cell types photoaging-associated shifts expression genes related extracellular matrix fibrosis. These widespread led dramatically altered cell-cell communication networks Most notably, predicted myeloid interactions with keratinocytes, fibroblasts, endothelial twice as abundant chronologically aged (sun-protected, For functional validation, challenges candida injection imiquimod application young volunteers. Treated sites biopsied performed, further corroborating immunological differences Together, our data capture at unparalleled resolution reveal profound alterations may underlie not only but its susceptibility infection neoplasm.
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2022
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2022.05.135